Protection only applies on the battlefield, so any card with protection from everything can be countered with Counterspell or removed from the hand entirely by Thoughtseize
Tocasia, Dig Site Mentor, Kestia, the Cultivator, Brenard, Ginger Sculptor, and Tuvasa the Sunlit all fit in here
It may seem like a heavy downside to discard your entire hand, but countless times you will end up in a situation where you have nothing to work with in your current hand and just need a completely fresh one
Kytheon, Hero of Akros definitely gets the checkmark for being Standard playable, but we might not see this guy breaking down tournament walls until Courser of Kruphix and Sylvan Caryatid becomes a thing of the past
When this creature dies, if it's not a token, create a token that's a copy of it, except it's an artifact in addition to its other types